منابع مشابه
Circadian control of glucose metabolism
The incidence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic proportions. The pathophysiology of T2DM is complex and involves insulin resistance, pancreatic β-cell dysfunction and visceral adiposity. It has been known for decades that a disruption of biological rhythms (which happens the most profoundly with shift work) increases the risk of developing obesity and T2DM. Re...
متن کاملMetabolism and the control of circadian rhythms.
The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve t...
متن کاملCircadian Post-transcriptional Control of Metabolism
Circadian clocks control thousands of genes, which ultimately generate rhythms in signaling pathways, metabolism, tissue physiology and behavior. Although rhythmic transcription plays a critical role in generating these rhythmic gene expression patterns, recent evidence has shown that post-transcriptional mechanisms are also important. Here we describe studies showing that regulation of mRNA po...
متن کاملCircadian control of epigenetic modifications modulates metabolism.
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متن کاملHormonal Control of Glucose Metabolism
Plasma glucose concentration is normally maintained within a narrow range despite wide fluctuations in the supply (meal) and demand (exercise) for nutrients. In adult humans, plasma glucose concentrations throughout a 24-hour period average 90 mg/ dl, with maximum values 60-90 minutes after meals, usually not exceeding 140 mg/ dl, and values during a moderate fast or exercise usually remaining ...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2014
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2014.03.002